NCT04450134

Histamine H1/H2 Receptors and Training Adaptations

Role of Histamine H1/H2 Receptors in the Health- and Performance-promoting Adaptations to High-intensity Interval Training

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: University Ghent · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Conditions

• Exercise Training
• Physical Activity

Interventions

Type	Name	Description
OTHER	Lactose	Placebo: Lactose capsules
DRUG	Fexofenadine Hydrochloride	H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride
DRUG	Famotidine	H2 receptor antagonist: 40 mg Famotidine
OTHER	High-intensity interval training (HIIT)	6 weeks HIIT

Timeline

• Start date: 2019-10-02
• Primary completion: 2019-12-18
• Completion: 2021-04-14
• First posted: 2020-06-29
• Last updated: 2024-06-07

Locations

1 site across 1 country: Belgium