NCT04447625

Intrauterine Antibiotic Infusion in Treating Chronic Endometritis and Restoring Reproductive Dynamics

Introducing Intrauterine Antibiotic Infusion as a Novel Approach in Effectively Treating Chronic Endometritis and Restoring Reproductive Dynamics: A Pilot Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Genesis Athens Clinic · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA), and it assesses respective performance against the gold standard treatment of OAA. Data sourced herein reports on treatment efficiency and fertility restoration for both patients aiming to conceive naturally or via In Vitro fertilization (IVF).

Conditions

• Chronic Endometritis

Interventions

Type	Name	Description
DRUG	Oral antibiotic administration	per os antibiotic administration as the standard line of strategy for treating CE of doxycycline at a dosage of 100mg twice a day for 14 days and metronidazole of 500mg twice a day for 14 days
DRUG	Intrauterine antibiotic infusion	intrauterine infusion of 3ml of ciprofloxacin at a concentration of 200 mg/100 ml

Timeline

• Start date: 2017-03-01
• Primary completion: 2019-02-28
• Completion: 2020-01-03
• First posted: 2020-06-25
• Last updated: 2020-06-25

Locations

1 site across 1 country: Greece