Trials / Completed
CompletedNCT04447131
Effect of COVID-19 on Platelet Aggregation
Effect of SARS-CoV-2 Infection on Platelet Aggregation and Other Coagulation Parameters
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 120 (actual)
- Sponsor
- University of Sao Paulo · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
This is a mechanistic, observational, prospective, case and control study, to compare platelet aggregation, analyzed by Multiplate-ADP, in hospitalized patients diagnosed with COVID-19 versus healthy controls. Thus will be included 60 patients who present with respiratory symptoms within 72 hours of hospitalization and confirmation of the diagnosis of COVID-19 by laboratory method (RT -PCR and / or positive serology for SARS-CoV-2 - COVID group); this group will be compared to 60 healthy individuals (asymptomatic and with negative SARS-CoV-2 serology), matched by sex and age to the previous group.
Detailed description
There is strong evidence that SARS-CoV-2 infection is associated with atherothrombotic phenomena. However, platelet activity in COVID-19 has not yet been studied. Thus, the main objective of this project is to evaluate platelet aggregation by the Multiplate-ADP method in hospitalized patients diagnosed with COVID-19, in comparison with the platelet aggregation evaluated by the same method in healthy controls. Secondary objectives include the assessment of parameters related to coagulation, inflammation, and clinical outcome variables. This is a mechanistic, observational, prospective, case and control study, which will include 60 patients who present with respiratory symptoms within 72 hours of hospitalization and confirmation of the diagnosis of COVID-19 by laboratory method (RT -PCR and / or positive serology for SARS-CoV-2 - COVID group); this group will be compared to 60 healthy individuals (asymptomatic and with negative SARS-CoV-2 serology), matched by sex and age to the previous group.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | venipuncture in peripheral vein | single vacuum venipuncture in peripheral vein |
Timeline
- Start date
- 2020-04-29
- Primary completion
- 2020-06-30
- Completion
- 2023-11-27
- First posted
- 2020-06-25
- Last updated
- 2025-04-25
Locations
2 sites across 1 country: Brazil
Source: ClinicalTrials.gov record NCT04447131. Inclusion in this directory is not an endorsement.