NCT04443946

Different Anesthesia Maintain Protocol Effect the Outcome of the Patients

Different Anesthesia Maintain Protocol Effect the Outcome of the Patients Undergoing General Anesthesia for Urinary Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: China International Neuroscience Institution · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This prospective open-label randomized study, patients were having elective urological surgery scheduled to last longer than 1 h under necessitating general anesthesia.Group-P: (Propofol group): 3 mg kg-1 min-1 propofol was pumped continuously after endotracheal intubation. Group-PAS: (Propofol and after 20 min adding Sevoflurane group): 3 mg kg-1 min-1 propofol were pumped continuously and add 1% end-tidal sevoflurane 20 minutes after endotracheal intubation. Group-PS: (Propofol and Sevoflurane group): 3 mg kg-1 min-1 propofol were continuously pumped after endotracheal intubation, and 1% sevoflurane was inhaled continuously at the same time. Group-S: (Sevoflurane group): 1% sevoflurane continued to maintain anesthesia after endotracheal intubation. Group-PSu: (Propofol and Sufentanil group): 3 mg kg-1 min-1 propofol, 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at maintain phase

Detailed description

Group-P: (Propofol group): 3 mg kg-1 min-1 propofol was pumped continuously after endotracheal intubation. Group-PAS: (Propofol and after 20 min adding Sevoflurane group): 3 mg kg-1 min-1 propofol were pumped continuously and add 1% end-tidal sevoflurane 20 minutes after endotracheal intubation. Group-PS: (Propofol and Sevoflurane group): 3 mg kg-1 min-1 propofol were continuously pumped after endotracheal intubation, and 1% sevoflurane was inhaled continuously at the same time. Group-S: (Sevoflurane group): 1% sevoflurane continued to maintain anesthesia after endotracheal intubation. Group-PSu: (Propofol and Sufentanil group): 3 mg kg-1 min-1 propofol, 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at maintain phase. Due to the ethical requirements of adequent analgesia, 0.3 μ g kg-1 min-1 remifentanil was continuously pumped as background input dose during anesthesia maintenance in all groups.

Conditions

• Urinary Surgery
• General Anesthesia

Interventions

Type	Name	Description
DRUG	Propofol	5 mg kg-1 h-1 propofol was pumped continuously after endotracheal intubation.
DRUG	1% Sevoflurane	add 1% end-tidal sevoflurane 20 minutes after endotracheal intubation.
DRUG	1% Sevoflurane continue	1% sevoflurane continued to maintain anesthesia after endotracheal intubation.
DRUG	Sufentanil	0.01 μ g kg-1 min-1 sufentanil were pumped continuously at maintain phase
DRUG	2% Sevoflurane	2% sevoflurane continued to maintain anesthesia after endotracheal intubation.
DRUG	Propofol half	2.5 mg kg-1 h-1 propofol was pumped continuously after endotracheal intubation.

Timeline

• Start date: 2020-06-25
• Primary completion: 2020-08-05
• Completion: 2020-08-05
• First posted: 2020-06-23
• Last updated: 2020-10-14

Locations

1 site across 1 country: China