NCT04443660

Autophagy/Apoptosis Balance During Pregnancy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 97 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications. The study investigators hypothesize that there would be an intra-trophoblastic dialogue between the mechanisms of autophagy and apoptosis, the promotion of one partially inhibiting the other. The increase in trophoblastic autophagy during pregnancy could thus constitute an anti-apoptosis defense phenomenon, the exhaustion of which would lead to cellular apoptosis and to pathogenic consequences when it devastates the syncytiotrophoblast.

Conditions

• Pregnancy Related

Interventions

Type	Name	Description
OTHER	Blood test	Blood samples taken to test levels of autophagy and apoptosis

Timeline

• Start date: 2020-12-30
• Primary completion: 2024-09-30
• Completion: 2025-04-07
• First posted: 2020-06-23
• Last updated: 2025-12-31

Locations

1 site across 1 country: France