NCT04442555

Treatment With the Ketone Body 3-hydroxybutyrate in Patients With Acute Heart Failure

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Background: Acute heart failure is a potentially life-threatening condition, reaching mortality rates of up to 50% in advanced cases. The investigators have shown that infusion of ketone bodies increase cardiac output by 40% in stabile patients with chronic heart failure. However, there are no data showing the effects of ketone on patients with acute heart failure Objectives: To investigate the effect of ketone supplementation in patients with acute heart failure and cardiogenic shock, using two different types of oral ketone supplements. Methods: The investigators will conduct four randomized placebo-controlled studies, to investigate the hemodynamic effect of exogenous ketones in acute heart failure and cardiogenic shock. Perspectives: The present study will determine the potential beneficial effects of ketone supplements in patients with acute heart failure.

Conditions

• Acute Heart Failure

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	HVMN Ketone Ester	Commercially available ketone supplement
DIETARY_SUPPLEMENT	Maltodextrin	Commercially available maltodextrin supplement

Timeline

• Start date: 2020-02-01
• Primary completion: 2023-03-30
• Completion: 2023-03-30
• First posted: 2020-06-22
• Last updated: 2022-07-18

Locations

1 site across 1 country: Denmark