NCT04441073

Lignocaine Nebulization for Attenuation of Intubation Stress Response

Lignocaine Nebulization for Attenuation of Intubation Stress Response in Patients With Severe Pre-eclampsia: a Prospective Double-blinded Placebo-controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

To study the effect of lignocaine nebulization on attenuation of the pressor response during induction and emergence of anesthesia in patients with severe pre-eclampsia

Detailed description

The pressor response to laryngoscopy and tracheal intubation is a very important issue in hypertensive pregnant patients that can lead to increased maternal intracranial pressure, cerebral haemorrhage, and cardiac failure with pulmonary oedema and may result in maternal mortality. The catecholamine release associated with laryngoscopy and intubation also causes uteroplacental vasoconstriction and adversely affect the neonate well-being. Therefore, the precise control of stress is necessary during general anesthesia in pre-eclamptic patients.Various drugs are used to suppress the pressor response including opioids, lidocaine, along with α and β adrenergic blockers. in this study the investigators will evaluate the effect of lignocaine nebulization on attenuation of the pressor response.

Conditions

• Pressor Response

Interventions

Type	Name	Description
DRUG	Lignocaine	preoperative nebulization of lignocaine
DRUG	Placebo	preoperative nebulization of normal saline (Nacl 0.9%) as a placebo

Timeline

• Start date: 2021-02-24
• Primary completion: 2022-02-23
• Completion: 2022-02-23
• First posted: 2020-06-22
• Last updated: 2022-01-19

Locations

1 site across 1 country: Egypt