NCT04440631

Gut Microbiome of Patients Undergoing Antibiotic Therapy for Orthopedic Device-related Infection

Investigation of the Microbiome of Patients Receiving Antibiotic Therapy for Orthopedic Device-related Infection

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 12 (actual)
• Sponsor: AO Research Institute Davos · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The microbiome of 80 orthopedic-device related infection (ODRI) patients treated with antibiotics and 10 healthy controls will be investigated. Samples (blood, stool, saliva, skin-swab) are collected 4x within 6 months. Composition and diversity of the microbiome will be assessed by 16sRNA sequencing, skins swabs are screened for rifampicin-resistant staphylococci onto Mannitol-salt-agar plates supplemented with rifampicin, inflammation markers and antibodies in blood and saliva are monitored to track changes in the immune response. For further analysis patients are assigned to one of two groups: 1) antibiotic therapy including rifampicin and 2) non-rifampicin antibiotic therapy.

Conditions

• Fractures, Bone
• Infection, Bacterial
• Joint Infection
• Bone Infection

Interventions

Type	Name	Description
OTHER	no intervention, observational only	no intervention, observational only

Timeline

• Start date: 2019-11-01
• Primary completion: 2022-06-01
• Completion: 2022-12-31
• First posted: 2020-06-19
• Last updated: 2023-02-03

Locations

2 sites across 1 country: Switzerland