NCT04439994

Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)

Activation of Plasma miRNA and Proteins as a Result of Acute Experimental Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

In this experiment, the investigators would like to test the following: 1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ? 2. Can these canges correlate with the development of local hyperalgesia? 3. How does the plasma miRNA expression change over a duration of 24 hours post pain induction ? 4. Which mRNA targets are potentially affected by acute pain?

Conditions

• Hypertonic Saline
• Isotonic Saline

Interventions

Type	Name	Description
OTHER	hypertonic saline	The participant will be given i.d. in 0.1 mL volumes of a hypertonic saline solution
OTHER	Saline injection	The participant will be given i.d. in 0.1 mL volumes of a saline solution
PROCEDURE	Blood sampling	Whole blood samples (5 mL per each time point, a total of 20 mL per subject) will be collected

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-07-01
• Completion: 2022-07-01
• First posted: 2020-06-19
• Last updated: 2023-10-03

Locations

2 sites across 1 country: Denmark