NCT04436224

Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation

Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation: A Dose-exploration and Effectiveness Study

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 530 (estimated)
• Sponsor: Nanfang Hospital, Southern Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hydromorphone has a clear analgesic effect, and has few advantages in respiratory depression and gastrointestinal motility. The study will further explore the continuous pumping-dose of hydromorphone for ICU non-mechanical ventilation patients and monitor its effective plasma concentration as well as evaluates the safety and effectiveness of hydromorphone for ICU non-mechanical ventilation patients.

Conditions

• Hydromorphone
• Analgesia
• ICU

Interventions

Type	Name	Description
DRUG	Hydromorphone	Intravenous analgesia using hydromorphone in ICU patients with non-mechanical ventilation(NS 40ML+ hydromorphone 10mg ，IV-Pump)
DRUG	Fentanyl	Intravenous analgesia using fentanyl in ICU patients with non-mechanical ventilation(NS 40ML+ fentanyl 0.5mg, IV-Pump)
DRUG	Butorphanol	Intravenous analgesia using butorphanol in ICU patients with non-mechanical ventilation(NS 40ML+ butorphanol 10mg，IV-Pump)

Timeline

• Start date: 2020-09-04
• Primary completion: 2022-06-01
• Completion: 2022-09-01
• First posted: 2020-06-17
• Last updated: 2022-01-20

Locations

1 site across 1 country: China