Trials / Unknown
UnknownNCT04431570
Repetitive Transcranial Magnetic Stimulation for the Treatment of Freezing of Gait in Parkinson's Disease
Repetitive Transcranial Magnetic Stimulation for the Treatment of Freezing of Gait in Parkinson's Disease: A Randomized Controlled Trial
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- Sponsor
- Peking Union Medical College Hospital · Academic / Other
- Sex
- All
- Age
- 50 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
Freezing of gait (FOG) is a common and devastating symptom in advanced stage Parkinson's disease (PD), which contributes to falls and disability. Unfortunately, there is no effective pharmacological treatment for FOG. It is suggested that the cortex-basal ganglia circuit, especially the frontal lobe, plays an important role in the pathogenesis of FOG. Repetitive transcranial magnetic stimulation (rTMS) effects over the cortex and affects the subcortical neural circuits. Previous studies have demonstrated that rTMS can improve FOG for PD patients. In the present randomized controlled trial (RCT) study, the invastigators aim to investigate the efficiency of rTMS over different motor regions of frontal lobe. The efficacy of treatment is evaluated by the score of FOG questionnaire and FOG provoking test, and the changing of neural network shown by functional magnetic resonance imaging (FMRI). Then the effects of rTMS over different brain regions will be compared for choosing a better target. The study will provide the evidence for non-invasive neuro-modulation of Parkinson's disease with freezing of gait (PD-FOG).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | rTMS | The device is made in London, United Kingdom |
| DEVICE | sham stimulation | the device of sham stimulation was MagStim MC-P-B70 placebo butterfly coil |
Timeline
- Start date
- 2020-06-15
- Primary completion
- 2022-04-14
- Completion
- 2022-06-14
- First posted
- 2020-06-16
- Last updated
- 2020-06-16
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04431570. Inclusion in this directory is not an endorsement.