NCT04430998

Efficacy of Zinc L-Carnosine Mouth Rinse

Efficacy of a Zinc-L-Carnosine -Based Mouth Rinse on Periodontal Tissues and Pain After Scaling and Root Planing - a Randomized Clinical Trial; a Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: University of Milan · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A clinical trial to assess the effect of a Zinc-L-Carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing

Detailed description

A randomized, double blind, 3 group parallel study with random allocation of 75 patients to any of three groups; Zinc-L-Carnosine-based mouth rinse, Chlorhexidine mouth rinse and placebo (water) control. Three days after professional oral hygiene, which aimed at the normalization of the periodontal index, the primary (HI, VAS) and secondary (mSBI; FMPS; VMI; SI) outcomes of the study are measured to obtain baseline information, and then scaling and root planing are carried out. The participants will be advised to follow their regular oral hygiene procedures (tooth brushing) in addition to the allocated mouth rinse. They will be examined again for primary and secondary outcomes at 7 and 21 days. Clinical evaluation: Clinical examination of each participant will be done by a single examiner using the previously described VAS scale and a UNC periodontal probe (No. 5 explorer Hu-Friedy, Chicago, Ill). In addition to these indices, each subject will be asked to report any adverse events they have encountered during the experiment.

Conditions

• Periodontal Index
• Pain

Interventions

Type	Name	Description
DRUG	Zinc L-Carnosine	Undiluted 10 ml of Zinc L-Carnosine mouth rinse, retain for 3 minutes, 3 times daily
DRUG	Chlorhexidine	Undiluted 10 ml of Chlorhexidine mouth rinse, retain for 3 minutes, 3 times daily
OTHER	Water	Rinse mouth with 10 ml of water, retain for 3 minutes, 3 times daily

Timeline

• Start date: 2020-06-01
• Primary completion: 2020-06-22
• Completion: 2020-06-30
• First posted: 2020-06-16
• Last updated: 2020-06-18

Locations

1 site across 1 country: Italy