NCT04430920

Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery

Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery (BP-CARES): A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,500 (actual)
• Sponsor: Nanfang Hospital, Southern Medical University · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

This study is a multicenter randomized controlled trial comparing an intensive intraoperative blood pressure management strategy versus conventional practice for preventing cardiovascular events in high-risk patients undergoing major abdominal surgery.

Detailed description

Intraoperative hypotension has been associated with cardiovascular events after non-cardiac surgery. However, whether avoiding intraoperative hypotension can reduce the incidence of postoperative cardiovascular events remains unclear. The objective of this study is to assess the effects of an intensive intraoperative blood pressure management strategy (to maintain intraoperative MAP ≥ 80mmHg) with that of conventional practice (to maintain intraoperative MAP ≥ 65mmHg) on the incidence of cardiovascular events after major abdominal surgery.

Conditions

• Cardiovascular Complication

Interventions

Type	Name	Description
OTHER	Intensive intraoperative blood pressure management	Targeting intraoperative mean arterial pressure ≥ 80 mmHg.
OTHER	Conventional intraoperative blood pressure management	Targeting intraoperative mean arterial pressure ≥ 65 mmHg or 60% of the baseline level (use the higher target).

Timeline

• Start date: 2020-06-30
• Primary completion: 2022-09-23
• Completion: 2025-04-08
• First posted: 2020-06-16
• Last updated: 2025-04-22

Locations

3 sites across 1 country: China