NCT04429685

The Effects of Low Dose Ketamine on Cardiovascular Function

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure. Blood pressure that is too high or too low can be problematic if untreated. It is unknown exactly how low dose ketamine affects blood pressure. In fact, no prior studies have measured sympathetic nervous system activity after low dose ketamine has been given to an adult. Because sympathetic nervous system activity has a large influence on blood pressure, we need to know how exactly low dose ketamine affects these body systems. Therefore, in this research we will study how low dose ketamine affects sympathetic nervous system activity and cardiovascular function. The results from this research will inform doctors about how low dose ketamine affects the sympathetic nervous system, heart, and blood vessels.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Ketamine	Low dose ketamine - Ketalar (Racemic Ketamine Hydrochloride) Saline - Isotonic/Normal Saline
DRUG	Saline (placebo)	Saline (placebo)

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-05-28
• Completion: 2021-05-28
• First posted: 2020-06-12
• Last updated: 2024-05-21

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study