NCT04428944

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

Strategies for Catheter Ablation of Persistent Atrial Fibrillation: a Randomized, Comparative Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 617 (actual)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: 1. PV antral isolation alone (PVAI) 2. PV antral isolation plus ablation of drivers (PVAI+drivers) 3. PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation technology using more efficient open irrigated tip cooling and contact force sensing.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI)	Standard PVI
PROCEDURE	Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers)	Standard PVI + Ablation of drivers in LA and RA
PROCEDURE	Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box)	Standard PVI + Electrical isolation of the posterior wall of the left atrium

Timeline

• Start date: 2021-06-01
• Primary completion: 2027-09-01
• Completion: 2027-12-01
• First posted: 2020-06-11
• Last updated: 2025-02-06

Locations

32 sites across 9 countries: United States, Australia, Austria, Belgium, Canada, France, Italy, Japan, Spain