Trials / Recruiting
RecruitingNCT04427891
Characteristics of Abdominal Fluid in Patients With Diverticulitis Hinchey III or IV
Study of Changes in Abdominal Fluid in Connection With Peritonitis. A Descriptive Study in Patients With Purulent or Fecal Peritonitis.
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Sahlgrenska University Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Perforated diverticulitis of the colon can be complicated by peritonitis, either purulent or fecal. Both are life threatening conditions requiring emergency surgery. The background in terms of reasons for inflammation (diverticulitis) and perforation to develop is unknown. In this study we focus on specific changes associated with inflammation, both in tissues and of fecal and mucosal microbiota.
Detailed description
A prospective study of abdominal fluid, periferal blood, tissues as well as feces in Patients (perforated diverticulitis with peritonitis undergoing emergency surgery, Group I), and in Controls (patients operated due to colorectal cancer, Group II; patients with mild diverticulitis not needing surgery, Group III). Immune acitvity in abdominal fluid and periferal blood by immunoassay of 92 individual proteins. mRNA expression of 96 specific genes in tissue samples. Quatification of bacterial diversity in feces and colon mucosa.
Conditions
Timeline
- Start date
- 2021-09-21
- Primary completion
- 2025-08-01
- Completion
- 2027-12-01
- First posted
- 2020-06-11
- Last updated
- 2025-05-25
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT04427891. Inclusion in this directory is not an endorsement.