NCT04423887

Effects of Creatine Supplementation in Addition to Resistance Exercise Training in Patients With Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Foundation University Islamabad · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Despite the past decade being dedicated to bone and joint disease, the incidence and prevalence rates of osteoarthritis continues to rise, and till date not curative treatment has been identified for the management of knee osteoarthritis. In terms of conservative management of knee osteoarthritis, pharmacological management has been the mainstay of treatment, however is associated with numerous adverse effects with prolonged use, and it is important to look into the non-pharmacological alternates for the management of knee osteoarthritis. Research has shown resistance exercise training to be the most effective non-pharmacological treatment option for the management of knee osteoarthritis, and the purpose of the current study is to determine if the addition of a non-pharmacological dietry supplement like creatine can amplify the beneficial effects of resistance exercise training in patients with knee osteoarthritis.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	Lower Extremity Resistance Exercise Training	Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM) 3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press, leg extension, Sit to stand squat (mini squats) Stationary Cycling (Maximum Resistance as per patient tolerance till failure) 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval
OTHER	Home Exercise Plan	2 sets of 10 repetitions/day of AROM isolated knee extension and knee flexion Isometric isolated knee extension and knee flexion Isometric terminal knee extension Sit to stand squat Isometric knee terminal extension
DEVICE	Electrotherapy + Heating	Interferential Current therapy (2P), in combination with heating pad for 20 minutes
PROCEDURE	Joint Mobilization	Tibio-femoral Anterior Glide Tibio-femoral Posterior Glide Patellofemoral Joint Mobilization
DIETARY_SUPPLEMENT	Creatine Supplementation	Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks

Timeline

• Start date: 2020-06-10
• Primary completion: 2020-12-06
• Completion: 2020-12-06
• First posted: 2020-06-09
• Last updated: 2020-12-09

Locations

1 site across 1 country: Pakistan