NCT04423627

Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

Sympathetic Regulation of Large Artery Stiffness in Humans With Age-Related Isolated Systolic Hypertension

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke. Nerve activity from your brain to your body also increases with advancing age but it is unknown if this nerve activity contributes directly to the stiffening on your blood vessels in older adults in addition to high blood pressure. Therefore, successful completion of the proposed aims will have a significant clinical impact by identifying if nerve activity from your brain could be a novel target for therapies that would lower stiffness of the aorta and carotid arteries in older adults.

Conditions

• Hypertension, Systolic
• Stiffness, Aortic

Interventions

Type	Name	Description
DRUG	Clonidine	Clonidine 0.2 mg/day oral tablet
DRUG	Hydrochlorothiazide	Hydrochlorothiazide 37.5 mg/day oral tablet
DRUG	Placebo	Placebo

Timeline

• Start date: 2021-06-01
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2020-06-09
• Last updated: 2025-08-08

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study