NCT04423432

Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Foundation University Islamabad · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	Lower Extremity Resistance Exercise Training	3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
OTHER	Home Exercise Plan	2 sets of 10 repetitions/day of 1. AROM isolated knee extension and knee flexion 2. Isometric isolated knee extension and knee flexion 3. Isometric terminal knee extension 4. Sit to stand squat terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
DEVICE	Electrotherapy + Heating	Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
PROCEDURE	Joint Mobilization	1. Tibio-femoral Anterior Glide 2. Tibio-femoral Posterior Glide 3. Patellofemoral Joint Mobilization
DIETARY_SUPPLEMENT	Creatine Supplementation	Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
DIETARY_SUPPLEMENT	Glucoseamine/ Chondritin Sulfate Supplementation	Glucoseamine/ Chondritin Sulfate Supplementation (500mg+400mg/day)

Timeline

• Start date: 2020-01-01
• Primary completion: 2020-11-01
• Completion: 2020-12-01
• First posted: 2020-06-09
• Last updated: 2020-06-09

Locations

1 site across 1 country: Pakistan