NCT04421092

Efficacy of SLN Block for Chronic Cough

Efficacy of Superior Laryngeal Nerve Block for Chronic Cough

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value). Eligibility for the study include the following: age \>18, cough history suggestive that the nerve to the voice box is overactive, non-smoker, Patients will be followed over time and assigned to either the treatment or placebo group at random. The treatment would be four superior laryngeal nerve blocks and the placebo would be four saline injections (the inactive substance). Study team will measure if the injection improved cough and ask patients to keep a log of symptoms and fill out questionnaires at each visit. After the four injections, patients will follow up in 3 months to see if cough has returned and if so, how severe the cough is.

Conditions

• Cough
• Superior Laryngeal Nerve Block
• Neurogenic Cough

Interventions

Type	Name	Description
PROCEDURE	Superior laryngeal nerve block	Injection of either the steroid-lidocaine mixture or placebo through the skin around where the superior laryngeal nerve is located on the neck. The procedure lasts 5 minutes and is done in the clinic.
PROCEDURE	Injection of placebo (saline)	Superior laryngeal nerve block using 1mL of saline as the injection.
PROCEDURE	Injection of steroid-lidocaine mixture	Superior laryngeal nerve block using 1mg 1:1 triamcinolone 40mg: 1% lidocaine with 1:200000 epinephrine as the injection.

Timeline

• Start date: 2020-07-22
• Primary completion: 2022-12-30
• Completion: 2022-12-30
• First posted: 2020-06-09
• Last updated: 2025-10-23
• Results posted: 2025-10-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study