NCT04420390

Low Dose Radiotherapy for COVID-19 Pneumonitis

Low Dose Radiotherapy as Antinflammatory Treatment for COVID-19 Pneumonitis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (estimated)
• Sponsor: Hospital San Carlos, Madrid · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to its high rate of infection and the high morbidity and mortality. The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting the immune response. Low dose radiotherapy (LD-RT) (≤ 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1β or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of LD-RT for SARS-CoV-2.

Conditions

• Covid19

Interventions

Type	Name	Description
RADIATION	Radiotherapy	Low-dose radiotherapy

Timeline

• Start date: 2020-05-01
• Primary completion: 2020-07-31
• Completion: 2020-09-08
• First posted: 2020-06-09
• Last updated: 2020-06-09

Locations

1 site across 1 country: Spain