NCT04419571

Outcomes in Emergency Laparotomies During COVID-19 Pandemic

Emergency Laparotomies and Outcomes During the COVID-19 Pandemic - a Retrospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 94 (actual)
• Sponsor: Barking, Havering and Redbridge University Hospitals NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. The investigators sought to assess if a similar correlation can be identified in emergency general surgical patients and if the presence of suspected or confirmed COVID-19 may impact on this. Given the heterogeneity of emergency general surgery the investigators therefore plan to perform a retrospective review of patients having emergency laparotomies only at a single NHS site during COVID-19 pandemic. Assessment of outcomes and Neutrophil:lymphocyte ratio as a predictor of outcomes will be completed. Outcomes will be completed in line with the recent COVIDSurg study criteria (3). The primary outcome is 30-day mortality. Secondary outcomes are 7-day mortality, re-operation, length of stay, post-operative respiratory failure, post-operative ARDS (Acute Respiratory Distress Syndrome), post-operative sepsis and ITU (Intensive Therapy Unit)/HDU (High Dependency Unit) admission.

Conditions

• COVID-19
• Emergency General Surgery

Interventions

Type	Name	Description
PROCEDURE	Emergency Laparotomy	All adult patients undergoing emergency laparotomy

Timeline

• Start date: 2020-03-23
• Primary completion: 2020-06-16
• Completion: 2020-06-16
• First posted: 2020-06-05
• Last updated: 2020-07-23

Locations

1 site across 1 country: United Kingdom