NCT04418960

Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease

Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease: an MRI-focused Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.

Conditions

• Barlow Disease (BD)
• Mitral Insufficiency

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Magnetic resonance imaging (MRI)	MRI pre- and postoperatively for detailed analysis of the ventricle and the mitral annulus. The first MRI will be performed on the admission day before surgery. The second MRI will be performed during the hospital stay, between 3 and 7 days after the operation. The MRI images are interpreted through a specialized cardiologist and radiologist.

Timeline

• Start date: 2018-09-21
• Primary completion: 2022-04-01
• Completion: 2022-04-01
• First posted: 2020-06-05
• Last updated: 2021-08-03

Locations

1 site across 1 country: Switzerland