NCT04416191

Immune Cells During Disuse and Recovery

Muscle Immune Cells During Disuse and Recovery in Aging and Metabolic Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week limb immobilization period.

Detailed description

Visit 1 (Pre-testing)- After signing a consent form, participants will undergo a blood screening and an oral glucose tolerance test. After the visit, participants will be provided with a step activity monitor to track their level of activity. A dietary assessment will also be determined. Visit 2- At a later time, the participant will return to the research center for a biopsy, blood draw, body composition scan, MRI and muscle strength testing. 2-week leg immobilization period- After visit 2 , the participant will return home and undergo a 14-day leg immobilization period using the equipment and instructions provided at visit 2. Visit 3- During the limb immobilization period, participant will return to the research center for a single blood draw. Visit 4- At the end of the 2-week limb immobilization period, the participant will return to the research center to undergo another biopsy, blood draw, body composition scan, MRI and muscle strength testing. Visit 5- 2 days after the 2-week limb immobilization period, the participant will return for a biopsy and blood draw. Visit 6- 7 days after the 2-week limb immobilization period, the participant will be asked to return for a final biopsy, blood draw, body composition scan, MRI and muscle strength testing.

Conditions

• Muscle Disuse

Interventions

Type	Name	Description
OTHER	Limb immobilization	Participants will undergo a 2-week period of leg immobilization

Timeline

• Start date: 2022-05-15
• Primary completion: 2027-04-30
• Completion: 2028-04-30
• First posted: 2020-06-04
• Last updated: 2025-12-05

Locations

1 site across 1 country: United States