NCT04414995

Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty

Effect of Paracetamol and Ibuprofen When Intravenously Given Combination or Alone in Reducing Morphine Requirements After Total Knee Arthroplasty

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Adequate pain management has an important role in supporting early ambulation after the Total Knee Arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of combination Paracetamol and Ibuprofen injection is expected to reduce total morphine consumption after TKA.

Detailed description

The research will compare the effect of paracetamol injection and ibuprofen injection when given alone or in combination to reduce morphine requirement in a patient after total knee arthroplasty

Conditions

• Analgesia

Interventions

Type	Name	Description
DRUG	Paracetamol injection and Ibuprofen injection	Use of combination acetaminophen and ibuprofen to reduce morphine requirement inpatient after Total knee arthroplasty
DRUG	Paracetamol injection and normal saline	Use of paracetamol and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty
DRUG	Ibuprofen Injection and normal saline	Use of ibuprofen and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty

Timeline

• Start date: 2020-06-05
• Primary completion: 2020-11-30
• Completion: 2020-12-15
• First posted: 2020-06-04
• Last updated: 2020-12-22

Locations

2 sites across 1 country: Indonesia