NCT04414423

Combination of Bone Marrow Concentrate and Iliac Cancellous Bone Graft in Alveolar Cleft Grafting

Combination of Bone Marrow Concentrate and Iliac Cancellous Bone Graft in Alveolar Cleft Grafting: a Clinical & Radiographic Evaluation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Fayoum University · Academic / Other
• Sex: All
• Age: 8 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study will be to analyze the newly formed bone volume and density, 6 months after alveolar cleft grafting using iliac cancellous bone graft, with and without bone marrow concentrate.

Detailed description

Twelve patients with unilateral alveolar cleft will be enrolled in this randomized comparative study. The patients will be divided into two groups, the control (group A) who received illiac cancellous bone graft and study group who received a combination of bone marrow concentrate and illiac cancellous bone graft (group B). Cone Beam CT (CBCT) images will be done prior to surgery to asses preoperative alveolar defect volume. Six months postoperative CBCT images will be done and postoperative newly bone formed volume and density will be evaluated and bone formation ratio (BF%) will be calculated as follows: BF% = (formed volume/alveolar defect) × 100%.

Conditions

• Alveolar Cleft Grafting

Interventions

Type	Name	Description
PROCEDURE	bone marrow concentrate alveolar cleft grafting	patients will undergo surgery to repair alveolar cleft with autogenous bone graft combined with bone marrow concentrate
PROCEDURE	Autogenous alveolar grafting	patients will undergo surgery to repair alveolar cleft with autogenous bone graft

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-11-20
• Completion: 2021-12-01
• First posted: 2020-06-04
• Last updated: 2021-12-07

Locations

2 sites across 1 country: Egypt