Trials / Unknown
UnknownNCT04414020
Cytoprotective Effect and Clinical Outcome of Perioperative Proesterone in Brain Tumors
- Status
- Unknown
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 26 (estimated)
- Sponsor
- Minia University · Academic / Other
- Sex
- All
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
Neuronal injury is evident in elective craniotomy for space occupying lesions. Surgical trauma and mechanichal impact of the tumor causes neuronal injury. Neurosreroid progesterone is a neurotransmittern , trail to use in abolishing neurotoxcicty
Detailed description
Progesterone is a natural neurosteroid that we are trying to use to impede both direct neuronal injury cauesd by and indirectly by surgical trauma. Progesterone can decreas vasogenic brain oedema. Our primary outcome is to ameliorate microscopic cytoplasmic injury and decrease brain oedema exploited by biopsy from brain tumor interface. Exclusion criteria demonstratd as refusal to participate in the trial , emergency craniotomy, recurrent brain tumor.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Progesteron | intramusculer progesterone |
Timeline
- Start date
- 2020-06-01
- Primary completion
- 2020-08-31
- Completion
- 2020-09-30
- First posted
- 2020-06-04
- Last updated
- 2020-06-04
Locations
2 sites across 1 country: Egypt
Source: ClinicalTrials.gov record NCT04414020. Inclusion in this directory is not an endorsement.