NCT04410315

Hyperlactatemia During and After Tumorcraniotomy

Elevated Serum-lactate in Patients With Brain Tumor During and After Elective Craniotomy: an Observational Clinical Study of Postoperative Patient Outcome.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 450 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy. The risk factors that induce lactat accumulation will also be explored.

Detailed description

Hyperlactatemia is a frequent occurrence in brain tumor surgery. The existing studies, however, are all retrospective, reporting varying effects on clinical outcome. One study reported new neurological deficitis, some found an association with extended hospital stay, while others found no association with outcome. It is therefore important to conduct a prospective study of hyperlactatemia in this patientgroup. Participants in this study will follow the standard treatment protocol for tumorcraniotomy, aside from 2-3 additional, perioperative blodgas analyses and 2 standardized measurements of neurological disability.

Conditions

• Hyperlactatemia
• Brain Tumor
• Surgery
• Anesthesia

Interventions

Type	Name	Description
OTHER	Serum-lactate < 2,2 mmol/L	Bloodgas analysis every hour from start surgery until recovery ward discharge
OTHER	Serum-lactate >/= 2,2 mmol/L	Bloodgas analysis every hour from start surgery until recovery ward discharge

Timeline

• Start date: 2020-07-28
• Primary completion: 2022-02-18
• Completion: 2022-02-18
• First posted: 2020-06-01
• Last updated: 2022-08-17

Locations

1 site across 1 country: Denmark