NCT04407065

Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles

Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles. A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 56 (estimated)
• Sponsor: Riyadh Fertility and Reproductive Health center · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (\<50%) number of oocytes retrieved per number of follicles \> 14 mm in diameter on day of hCG administration

Conditions

• Infertility, Female

Interventions

Type	Name	Description
DRUG	Double trigger	Final follicular maturation is triggered by the co-administration of GnRH-agonist (Triptorelin acetate, decapeptyl 0.2 mg, Slough, United Kingdom) and 10000 IU of HCG, 40 and 34 h prior to oocyte retrieval, respectively
DRUG	HCG trigger	Final follicular maturation is triggered by a dose of 10000 IU of HCG 36 h prior to oocyte retrieval

Timeline

• Start date: 2020-05-30
• Primary completion: 2020-12-30
• Completion: 2021-02-02
• First posted: 2020-05-29
• Last updated: 2020-05-29

Locations

1 site across 1 country: Egypt