NCT04406402

L-arginine and Asymmetric Dimethylarginine (ADMA) and Lifestyle Protocols

The Effects of Different Acute Nutritional Protocols and Lifestyle Modification on Circulating L-arginine and Asymmetric Dimethylarginine (ADMA) in Obese and Type 2 Diabetic Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 243 (actual)
• Sponsor: Tel-Aviv Sourasky Medical Center · Other Government
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Low serum L-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes (T2DM). The investigators examined whether or not Arg and ADMA are affected by dietary factors or lifestyle modification in overweight/ obese and T2DM subjects.

Detailed description

The investigators tested the effects on serum Arg and ADMA of a) a single load of ingested dextrose, protein, fat or alcohol, each consumed within 10 minutes; b) a single episode of physical exercise; c) a 12 weeks lifestyle modification program comprised of a standard dietary and physical activity counseling in obese or T2DM subjects on circulating Arg and ADMA (n=43)

Conditions

• Diabetes Mellitus, Type 2
• Obesity
• Arginine
• Asymmetric Dimethylarginine

Interventions

Type	Name	Description
BEHAVIORAL	Acute dietary protocols and lifestyle modification	The investigators tested the effects on serum Arg and ADMA of a) a single load of ingested dextrose, protein, fat or alcohol, each consumed within 10 minutes; b) a single episode of physical exercise; c) a 12 weeks lifestyle modification program comprised of a standard dietary and physical activity counseling in obese or T2DM subjects on circulating Arg and ADMA (n=43).

Timeline

• Start date: 2006-12-05
• Primary completion: 2008-04-04
• Completion: 2008-12-10
• First posted: 2020-05-28
• Last updated: 2020-06-02

Locations

1 site across 1 country: Israel