NCT04399642

Intra-articular Vancomycin Powder in Knee and Hip Arthroplasty

Intra-articular Vancomycin Powder in Knee and Hip Arthroplasty: a Prospective, Randomized Clinical Survey

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,832 (estimated)
• Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare infection rates when patients, elected for primary or aseptic revision THA / TKA, have a single intravenous antibiotic dose versus one single intravenous antibiotic dose in combination with intra-articular antibiotics. This is a prospective, randomized clinical survey on selected outcome measurements on 1834 subjects who will be recruited in a period of about 2 years.

Detailed description

Group A: patients receiving single dose of IV cefazolin 10-60 minutes before incision. Group B: patients receiving a single dose of IV cefazolin 10-60 minutes before incision + a single dose of intra-articular vancomycin powder before articulation (hip or knee) closure.

Conditions

• Infection

Interventions

Type	Name	Description
PROCEDURE	Arthroplasty	All patients include in the study will undergo a lowerlimb arthroplasty, primary or revision

Timeline

• Start date: 2019-07-05
• Primary completion: 2025-12-31
• Completion: 2027-12-31
• First posted: 2020-05-22
• Last updated: 2025-09-11

Locations

1 site across 1 country: Canada