Trials / Unknown
UnknownNCT04398069
Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- Sponsor
- Mongi Slim Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase. patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses: * Group 1: standard hemodynamic goals and catecholamin infusion to achieve: mean arterial pressure \> or equal to 65 mmHg and diastolic arterial pressure \> ou equal to 50 mmHg within the first 60 minutes. * Group 2: personalized hemodynamic goals and catecholamin infusion until normal transcranial doppler: IP\<1,2.
Detailed description
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase. patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses: * Group 1: standard hemodynamic goals and cathecolamin infusion to achieve: mean arterial pressure \> or equal to 65 mmHg and diastolic arterial pressure \> ou equal to 50 mmHg within the first 60 minutes. * Group 2: personalized hemodynamic goals and cathecolamin infusion until normal transcranial doppler: IP\<1,2. For the 2 groups, standard management including: microbiological sampling, early broad spectrum anti infective therapy, fluid management and decreasing of blood lactate levels, will be aimed within the first 60 minutes. For the Group 2 patients: personalized hemodynamic management will be maintained during 72 hours.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | hemodynamic optimisation aiming to achieve normal cerebral perfusion | hemodynamic optimisation aiming to achieve normal cerebral perfusion: titration of catecholamin infusion. |
Timeline
- Start date
- 2020-01-02
- Primary completion
- 2020-08-31
- Completion
- 2020-10-30
- First posted
- 2020-05-21
- Last updated
- 2020-05-21
Locations
1 site across 1 country: Tunisia
Source: ClinicalTrials.gov record NCT04398069. Inclusion in this directory is not an endorsement.