NCT04397354

Intracochlear Dexamethasone Application During Cochlear Implantation for Preserving Cochlear Cells

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Pamukkale University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The protection of cochlear cells is one of the main concerns of cochlear implant surgery. New electrode designs or additional molecules have been used for this purpose. The aim of the study is to test the effect of dexamethasone in two different application methods.

Detailed description

The protection of cochlear cells is one of the main concerns of cochlear implant surgery. New electrode designs or additional molecules have been used for this purpose. The aim of the study is to test the effect of dexamethasone in two different application methods. Participants who will have cochlear implant surgery will be divided into three groups. Group 1 will have intracochlear dexamethasone after the incision of the round window membrane. Group 2 will have intratympanic dexamethasone after the incision of the round window membrane. Group 3 will serve as a control group. All participants will be tested after a week, a month, 3, and 6 months. Impedance and threshold measurements will be compared.

Conditions

• Hearing Loss, Sensorineural

Interventions

Type	Name	Description
DRUG	Intracochlear Dexamethasone	intracochlear injection of dexamethasone with cochlear implantation
DRUG	Intratympanic Dexamethasone	intratympanic injection of dexamethasone with cochlear implantation
DRUG	No additional drugs(control Group)	Control group: No drugs will be injected middle ear with cochlear implantation

Timeline

• Start date: 2020-03-02
• Primary completion: 2022-08-01
• Completion: 2022-09-20
• First posted: 2020-05-21
• Last updated: 2023-01-04

Locations

1 site across 1 country: Turkey (Türkiye)