NCT04396730

Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess how Cannabidiol (CBD) impacts the effectiveness of oral contraceptive (birth control) pills and if CBD changes the possible side effects of birth control pills when CBD and birth control pills are taken at the same time. This study explores the potential interaction between CBD and birth control pills by assessing serum levels of the contraceptive steroid hormones ethinyl estradiol and levonorgestrel in birth control pill users when they also use CBD.

Detailed description

Participants will be randomized to either the CBD or placebo for cycle one, followed by a washout cycle. For cycle three, participants will take the opposite of what they received in Cycle one. For example if they received CBD during cycle one they will take placebo for cycle 3.

Conditions

• Contraception

Interventions

Type	Name	Description
DRUG	Cannabidiol Oil	400 mg Cannabidiol oil will be administered daily along with oral contraceptives daily for 24 days.
DRUG	Placebo	Placebo will be administered daily along with oral contraceptives daily for 24 days.
DRUG	Combined oral contraceptive pill	All participants will receive oral contraceptives

Timeline

• Start date: 2020-04-08
• Primary completion: 2022-03-02
• Completion: 2022-03-02
• First posted: 2020-05-21
• Last updated: 2023-07-11

Locations

1 site across 1 country: United States