NCT04394897

Total Intravenous Anesthesia With Remifentanil-propofol Admixture

Total Intravenous Anesthesia With Remifentanil-propofol Admixture Using Single-infusion Technique

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 96 (actual)
• Sponsor: Bezmialem Vakif University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Background: Application of total intravenous anesthesia (TIVA) may be considered as unpractical when compared with inhalational anesthesia. Although it is mostly not recommended, mixing intravenous agents seems to be popular in clinical practice. The aim of the study was to investigate the possible clinical drawbacks of using remifentanil-propofol admixture (MIXTIVA) for TIVA.

Detailed description

ASA I-II adult patients scheduled for elective thyroidectomy were randomly allocated into 3 groups (n= 32 for each) to have TIVA either with remifentanil and propofol infusions separately (control group, Group I) or with MIXTIVA infusion that had remifentanil/propofol proportion 2/1000 or 3/1000 (remifentanil concentration 20 µg/ml or 30 µg/ml in propofol 1%, Group II or Group III respectively). This technique may be considered as a practical implementation for busy ambulatory surgery centers performing general anesthesia, but delayed recovery may be predicted with longer duration of surgery and anesthesia.

Conditions

• Total Intravenous Anesthesia
• Propofol
• Remifentanil
• Bispectral Index Monitoring

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Remifentanil-Propofol admixture

Timeline

• Start date: 2013-03-12
• Primary completion: 2014-04-12
• Completion: 2014-04-12
• First posted: 2020-05-20
• Last updated: 2020-05-20