NCT04391478

Efficacy and Safety of Milrinone Versus Sildenafil in the Treatment of Neonates With Persistent Pulmonary Hypertension

Milrinone Versus Sildenafil in Treatment of PPHN in Neonates

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Rania Ali El-Farrash · Academic / Other
• Sex: All
• Age: 1 Hour – 10 Days
• Healthy volunteers: Not accepted

Summary

Compare the effect of milrinone versus sildenafil in treatment of neonates with persistent pulmonary hypertension.

Detailed description

40 neonates with PPHN, met inclusion criteria, randomly assigned to 2 groups, each includes 20, first group received intravenous milrinone and second group received nasogastric sildenafil. both groups receive other supportive care.

Conditions

• Persistent Pulmonary Hypertension

Interventions

Type	Name	Description
DRUG	Milrinone	milrinone lactate, 1mg/ml, for intra venous use only
DRUG	Sildenafil	50mg sildenafil citrate/tablet, crushed in water taken by nasogastric tube

Timeline

• Start date: 2015-01-01
• Primary completion: 2015-04-01
• Completion: 2015-09-01
• First posted: 2020-05-18
• Last updated: 2020-05-18