NCT04387955

Analysis of Chilblains pROfile During coVID-19 Epidemic (ACROVID)

Analysis of Chilblains Profile During COVID-19 Epidemic

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Accepted

Summary

Cases of chilblains have been reported with an unusual frequency in France in the context of the COronaVirus Infectious Disease 2019 (COVID-19) epidemic. Some of these cases have been linked to a virological status in favour of a recent Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection. Chilblains are acral inflammatory lesion typically reactive to cold (primary form). There are secondary forms acquired during autoimmune connectivitis such as lupus chilblain or hereditary forms related to type I Interferonopathy. An interferon type I signature has been described in these secondary forms of frostbite but also during the cytokine storm of severe forms of CoV-2 SARS infection. If cases of frostbite are indeed secondary to an SARS-CoV-2 infection, comparative analysis of their immunopathological profiles could provide a better understanding of the inflammatory mechanisms during COVID-19.

Conditions

• COVID-19
• Chilblains

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biological Sample Collection	* Diagnostic test : biological sample collection at Day 0 * Two skin biopsies on chilblain at Day 0 (one biopsy for histological analysis, one biopsy for basic research) * Anal swabbing at Day 0 * Blood test at Day 0 * Blood test at Month 1 * Blood test at Month 2

Timeline

• Start date: 2020-04-30
• Primary completion: 2021-07-30
• Completion: 2021-07-30
• First posted: 2020-05-14
• Last updated: 2021-11-29

Locations

1 site across 1 country: France