NCT04387058

Incidence of Diabetes and Metabolic Disorders After TIPS in Cirrhotic Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 111 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Decompensated cirrhosis is associated with sarcopenia. TIPS is an efficient treatment of portal hypertension. Based on our retrospective data, TIPS induces in 30% of cirrhotic patients metabolic disorders associated with diabetes or pre-diabetes. The main objective is to measure the cumulative incidence of diabetes and pre-diabetes 6 months after TIPS insertion.

Detailed description

Based on our retrospective data, we expect that one-third of cirrhotic patients develop glucose dysregulation after TIPS. A better knowledge of the metabolic disorders related to the TIPS could allow to prevent the deleterious effects of the TIPS on the disease (decrease of the insulin-sensitivity, fat gain ...), by simple interventions on diet or physical activity. We will assess the incidence of diabetes and pre-diabetes, and the influence of TIPS on nutritional status and sarcopenia. Patients will be follow-up 6 months after TIPS. We will explore the hormonal mechanisms that explain these changes.

Conditions

• Cirrhosis Portal

Interventions

Type	Name	Description
DEVICE	TIPS	TIPS (Transjugular Intrahepatic Portosystemic Shunt) is an interventional radiology method that creates an anastomosis between the portal venous network and the hepatic venous network.

Timeline

• Start date: 2019-06-16
• Primary completion: 2022-06-16
• Completion: 2022-06-16
• First posted: 2020-05-13
• Last updated: 2020-05-13

Locations

1 site across 1 country: France