Trials / Completed
CompletedNCT04385446
Comparative Study of Muc5ac and Muc2 Mucins in Tear Film Concentration in Surgical Treated Pterygia Patients
Comparative Study of Concentration of Muc5ac and Muc2 Mucins in Tear Film in Surgical Treated Pterygia With Amniotic Membrane Transplantation vs. Conjunctival Autograft
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 44 (actual)
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
To identify and compare the differences in the concentration of the Muc2 and Muc5AC mucins in tear film in patients who underwent pterygium surgery using amniotic membrane transplantation and conjunctival autograft surgery.
Detailed description
Patients with nasal, primary pterygium bigger than 1 mm of corneal invasion with residence in Mexico City and older than 18 years were included. Under informed consent, patients were divided into two groups in a random fashion. Pterygium surgery was carried out with conventional technique performing amniotic membrane transplantation for group A, and conjunctival autograft for group B. Muc2 and muc5ac mucin concentration was measure min tear film by ELISA; samples were taken before surgery, at first, third and sixth month postoperatively. BUT was also measured on the same dates. Descriptive statistics and the U-Mann Whitney test for independent groups, considering a p≤0.05 as significant were used for analysis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Amniotic membrane transplantation | Amniotic membrane transplantation was used as covering material during pterygium surgery. |
Timeline
- Start date
- 2016-02-02
- Primary completion
- 2017-02-07
- Completion
- 2018-09-05
- First posted
- 2020-05-13
- Last updated
- 2020-05-13
Source: ClinicalTrials.gov record NCT04385446. Inclusion in this directory is not an endorsement.