Trials / Unknown
UnknownNCT04384783
To Explore the Effect of GH Pretreatment on Clinical Outcomes in Patients With Low Ovarian Reserve
To Explore the Effect of Low-dose Long Term Growth Hormone Pretreatment on Clinical Pregnancy Outcomes in Patients With Low Ovarian Reserve
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 114 (estimated)
- Sponsor
- Guangzhou First People's Hospital · Academic / Other
- Sex
- Female
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Growth hormone (GH) has been used in the field of assisted reproduction technology for over 30 years. Studies for GH have been exploring in the applicable population, drug dosage, starting time and time limitation. In previous clinical applications, it worked as an adjuvant drug for improving ovarian reactivity. With the development of basic research and clinical applications, the improvement effect on egg quality is gradually recognized. However, which protocol of GH may work well and maximize the clinical effect remains mystery. The investigators' previous self-controlled retrospective research about 380 cases treated with GH found that the average daily injection of GH dose of 2IU for about 6 weeks can significantly improve embryo quality and clinical pregnancy outcomes of the patients with low ovarian response. The new POSEIDON standard clearly groups people with low prognosis and better classifies heterogeneous people, which may help classifying the specific subgroup that benefit most from GH of poor ovarian response (POR). The investigators design a prospective cohort study to explore whether GH low-dose long-term pretreatment can improve the outcome of assisted pregnancy and its possible mechanism in people with low ovarian reserve.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | growth hormone | growth hormone was adjuvanted 2IU/d from previous menstrual period for about six weeks. |
Timeline
- Start date
- 2020-05-26
- Primary completion
- 2022-04-30
- Completion
- 2022-04-30
- First posted
- 2020-05-12
- Last updated
- 2020-05-21
Source: ClinicalTrials.gov record NCT04384783. Inclusion in this directory is not an endorsement.