NCT04383561

Relationship Between LRG and Periodontal Disease

Leucin-rich alpha2 Glycoprotein (LRG): A Novel Acute Phase Protein Related With Stage 3 Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Aydin Adnan Menderes University · Academic / Other
• Sex: All
• Age: 26 Years – 49 Years
• Healthy volunteers: Accepted

Summary

This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.

Detailed description

Twenty-five stage 3 periodontitis and twenty-five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6 weeks after treatment. LRG, IL-6 and TNF-α were determined by ELISA.

Conditions

• Periodontitis
• Acute-Phase Response
• Inflammation

Interventions

Type	Name	Description
OTHER	Non-surgical periodontal treatment	Scaling and root planing (SRP), in four clinical visits
OTHER	Oral hygiene instructions	Oral hygiene instructions includes brushing with the modified Bass technique, interdental cleaning with dental floss and interdental brushes.

Timeline

• Start date: 2019-09-30
• Primary completion: 2020-01-15
• Completion: 2020-02-15
• First posted: 2020-05-12
• Last updated: 2020-05-12

Locations

1 site across 1 country: Turkey (Türkiye)