NCT04383093

Tadalafil Plus Tamsulosin for Male LUTS and ED

Prospective Observational Trial of Combination Therapy of Tadalafil 5mg Plus Tamsulosinmg for Men With Lower Urinary Tract Symptoms and Erectile Dysfunction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 75 (actual)
• Sponsor: University of Florence · Academic / Other
• Sex: Male
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Metabolic Syndrome (MetS) is a complex epidemic disorder with an impact on both lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Combination therapy of daily tadalafil and tamsulosin may provide relief to both diseases. Aim of the present study is to assess the impact of combination therapy of Tadalafil 5mg plus Tamsulosin 0.4mg on LUTS and ED, according to presence vs. absence of Mets.

Detailed description

75 Consecutive men presenting with ED and LUTS suggestive of bladder prostatic obstruction were enrolled. Patients were divided into two groups according to MetS presence or absence. All subjects were then treated with tadalafil 5 mg/die plus tamsulosin 0.4 mg/die for 12 weeks. Patients were re-evaluated after 12 weeks of treatment with Uroflowmetry and PVR, IPSS, IPSS QoL, OAB-q and IIEF-5 and comparison were made in and between groups.

Conditions

• Prostatic Hyperplasia, Benign
• Lower Urinary Tract Symptoms
• Erectile Dysfunction
• Metabolic Syndrome

Interventions

Type	Name	Description
DRUG	Tadalafil 5mg	Combination therapy of daily tadalafil plus tamsulosin

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2020-05-11
• Last updated: 2020-05-11