Trials / Unknown
UnknownNCT04381598
Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.
Efficacy of Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetic Patients With Periodontitis-A Split Mouth Randomized Controlled Trial.
- Status
- Unknown
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 19 (estimated)
- Sponsor
- SVS Institute of Dental Sciences · Academic / Other
- Sex
- All
- Age
- 20 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
With the increase in the incidence of diabetes and obesity, among other artificial sweeteners the need of natural non-caloric sweetener with acceptable taste and without any adverse effects is demanding.So,the use of stevia presents beneficial effects to general and oral health and its properties could result potentially effective in the treatment of periodontal diseases.
Detailed description
Stevia is considered as a novel molecule, because it is 100% natural and non caloric sweetener, with more sweetness than sucrose, without any adverse effects. It also demonstrates multiple benefits like anti-plaque effect, anti-diabetic effect, anti-periodontophatics properties, anti-hypertensive properties, anti-cariogenic properties etc. There are many studies conducted on stevia in humans, which justifies my study.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | stevia rebaudiana bertoni | Stevia has an anti-plaque effect because of its ability in decreasing the formation of bacterial insoluble polymers.It significantly decreases the production of TNF-R and IL-1a and slightly decreases the production of NO in stimulated cells with LPS and THP-1 showing its anti-inflammatory properties.These characteristics in combination with anti-diabetic properties could results in the effective treatment of periodontal diseases. |
| OTHER | placebo | A placebo without the active drug will be placed in the control sites. |
Timeline
- Start date
- 2019-04-01
- Primary completion
- 2020-10-01
- Completion
- 2021-11-01
- First posted
- 2020-05-11
- Last updated
- 2020-05-11
Locations
1 site across 1 country: India
Source: ClinicalTrials.gov record NCT04381598. Inclusion in this directory is not an endorsement.