NCT04375020

GABA and Beta-cell Regeneration

GABA From Medical Nutrition to Pancreatic Beta-cell Regeneration

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Ministry of Health and Population, Egypt · Other Government
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: —

Summary

GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.

Detailed description

100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients. All the patients Lied between 18-25 years old with 5-10 years of diabetes onset. The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day. The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily. In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment. In the second group,the investigator measured c peptide levels and anti-gad antibodies at the beginning of the trial and after 6 months.

Conditions

• Diabetes Mellitus, Type 1

Interventions

Type	Name	Description
DRUG	GABA	GABA nutritional supplement 750mg per day for 6 months

Timeline

• Start date: 2019-11-01
• Primary completion: 2020-05-01
• Completion: 2020-05-02
• First posted: 2020-05-05
• Last updated: 2020-05-07

Locations

1 site across 1 country: Egypt