NCT04374799

Heparin vs Placebo for Cardiac Catheterization

A Randomized Trial of Heparin vs Placebo in Patients Undergoing Cardiac Catheterization Via the Trans-radial Approach

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,623 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing cardiac catheterization will be randomized to 3 groups: no anticoagulant, low dose anticoagulant and high dose anticoagulant.

Detailed description

Patients undergoing diagnostic cardiac catheterization via the trans-radial approach will be randomly allocated (1:1:1) to receive either low-dose UFH (25 IU/Kg -maximal dose 3,000 IU), high-dose UFH 50 IU/kg -maximal dose 5,000 IU) or N/S 0.9%. After 30 minutes, patients will undergo a gradual wrist band release. Hematoma and radial artery occlusion will be assessed.

Conditions

• Cardiac Disease

Interventions

Type	Name	Description
DRUG	Heparin	two doses of heparin
DRUG	Placebos	placebo

Timeline

• Start date: 2020-10-05
• Primary completion: 2026-08-01
• Completion: 2026-12-01
• First posted: 2020-05-05
• Last updated: 2026-02-20

Locations

2 sites across 1 country: Canada