NCT04374474

Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)

Olfactory Retraining Therapy and Budesonide Nasal Rinse for Anosmia Treatment in Patients Post-CoVID 19. A Randomized Controlled Trial

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms. Nasal irrigations will be prescribed to all three groups (BID). In addition, one arm will receive a paper hand-out about post-viral anosmia with instructions to smell common household items (current care) and act as a control group. The second group will receive an essential oil retraining kit, whereas the third group will receive the same olfactory training kit and a prescription to use budesonide with the nasal irrigations. Olfactory scores will be tested at the enrollment, 3 months and at 6 months.

Conditions

• Olfactory Disorder

Interventions

Type	Name	Description
OTHER	Olfactory retraining	Olfactory retraining Olfactory training is performed by exposing patients twice daily to essential oils with four specific odors, present in glass jars with soaked cotton pads: phenyl ethyl alcohol, rose; eucalyptol, eucalyptus; citronellal, lemon; eugenol, cloves.
DRUG	corticosteroid nasal irrigation	Nasal irrigation with corticosteroid (budesonide) consists of 240-mL nasal irrigation with Pulmicort Respules (0.5mg) across both nose sides via NeilMed Sinus Rinse bottle (Santa Rosa, California, USA).
OTHER	smell household Items	Participants will receive a paper hand-out about post-viral anosmia with instructions to smell common household items
OTHER	Nasal Irrigation	Participants from all three groups will use nasal rinse (NeilMed Sinus Rinse) two times a day.

Timeline

• Start date: 2021-01-10
• Primary completion: 2021-12-10
• Completion: 2022-03-10
• First posted: 2020-05-05
• Last updated: 2025-08-01

Locations

1 site across 1 country: Canada