NCT04371237

Accelerating Post-exercise Muscle Glycogen Resynthesis in Humans: Impact of Combined Nutrient Intake and Intermittent Pneumatic Compression or Heat Therapy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: PepsiCo Global R&D · Industry
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

To determine if modalities designed to improve blood flow combined with post-exercise nutrient intake will improve replenishment of muscle glycogen better than nutrient intake alone. A secondary objective is to compare the effectiveness of heat therapy and intermittent pneumatic compression on glycogen replenishment.

Conditions

• Muscle Recovery
• Muscle Soreness
• Glycogen Depletion

Interventions

Type	Name	Description
DEVICE	Compression sleeve	From foot to hip/groin on both legs with only 1 leg connected to pneumatic pump for 1 hour
DEVICE	Heat therapy	Custom leg garment with one leg heated by circulating hot water approx 40 degrees C, the other leg approx 32 degrees C (thermoneutral) for 1 hour
OTHER	Glycogen-depleting exercise session	Prolonged intermittent high intensity running (LIST protocol)
OTHER	Nutrient Intake (beverage)	Post-exercise, all participants will receive a beverage containing 1.0 g/kg carbohydrate and 0.3 g/kg protein from the mixture of Gatorade Recover Protein Shake and Gatorade Thirst Quencher
PROCEDURE	Skeletal muscle biopsy	Vastus lateralis muscle in the lower thigh will be obtained by the percutaneous needle technique

Timeline

• Start date: 2018-09-19
• Primary completion: 2019-12-21
• Completion: 2019-12-21
• First posted: 2020-05-01
• Last updated: 2021-03-10

Locations

1 site across 1 country: United States