NCT04366791

Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19

The RESCUE 1-19 Trial: Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19

• Status: Terminated
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This phase I/II trial studies low-dose radiation therapy as a focal anti-inflammatory treatment for patients with pneumonia or SARS associated with COVID-19 infection.

Detailed description

PRIMARY OBJECTIVE: I. To compare treatment of COVID-19 between best supportive care plus provider's treatment choice versus best supportive care plus low-dose, whole-lung radiation therapy OUTLINE: Patients undergo 1 fraction of low-dose radiation therapy. After completion of study treatment, patients are followed up at days 1-7, and 14 after last dose of intervention.

Conditions

• Pneumonia
• Coronavirus Infection in 2019 (COVID-19)
• Severe Acute Respiratory Syndrome (SARS) Pneumonia

Interventions

Type	Name	Description
RADIATION	Low Dose Radiation Therapy	Undergo low-dose radiation therapy

Timeline

• Start date: 2020-04-24
• Primary completion: 2022-03-11
• Completion: 2022-03-11
• First posted: 2020-04-29
• Last updated: 2022-03-29

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated device study