NCT04366700

Evaluate the Effect of Graft and Membrane on Healing of Apicomarginal Defects

Evaluate the Effect of Graft and Membrane on Healing of Apicomarginal Defects: A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Postgraduate Institute of Dental Sciences Rohtak · Academic / Other
• Sex: All
• Age: 16 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will compare the effect of guided tissue regeneration using a mixture of autograft and PRF covered with a collagen membrane as compared to the membrane alone in the healing of apicomarginal defects. Healing of the lesions will be compared 2 dimensionaly and 3 dimensionaly using CBCT.

Detailed description

Patients with apicomarginal defects as per the inclusion criteria will be randomly divided into two groups -in test group 1 -the defects will be filled with a mixture of autograft(which will be obtained from the surrounding buccal cortical plate by using a trephine bur) and prf(will be prepared by Choukron's method) and the defects and denuded root surface will be covered with a collagen membrane and in test group 2 -the defects will be filled with a blood clot and over that the collagen membrane will be placed. Radiographic and clinical healing will be assessed after 12 months, 2D healing will be assessed by Rud and Molven criteria and 3D healing will be assessed by Modified Penn 3D criteria.The clinical parameters recorded including periodontal pocket depth (PD), clinical attachment level (CAL) and gingival margin position (GMP) and will be measured on buccal aspect of the interproximal space and mid buccal aspect of the involved teeth using Williams 'O' periodontal probe.Routine examination procedure will be used to evaluate any evidence of signs and/or symptoms.. The criteria for a successful outcome included the absence of clinical signs and/or symptoms and radiographic evidence of complete or incomplete healing.

Conditions

• Apicomarginal Defects

Interventions

Type	Name	Description
PROCEDURE	Periapical surgery with autograft and collagen membrane	periapical surgery will be done and the defects will be filled with a mixture of autograft and prf and will be covered with a collagen membrane
PROCEDURE	Periapical surgery with collagen membrane	periapical surgery will be done and the defects will be filled with blood clot and covered with a collagen membrane

Timeline

• Start date: 2018-11-01
• Primary completion: 2020-09-01
• Completion: 2020-09-01
• First posted: 2020-04-29
• Last updated: 2020-05-05

Locations

1 site across 1 country: India