NCT04365777

EEG Characteristics of Different Sedation Depths in Neurosurgery Patients

EEG Characteristics of Different Sedation Depths in Patients With Supratentorial Glioma in Frontal Lobe

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 42 (actual)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments are susceptible to external influences. Therefore, more objective evidence is needed to support and extend the existing conclusions. The purpose of this study is to compare the EEG signatures (such as the EEG signal power) at various levels of anesthetics induced sedation in patients with supratentorial glioma in frontal lobe and in patients without intracranial-occupying lesion.

Conditions

• Electroencephalography

Interventions

Type	Name	Description
OTHER	OAA/S=5	Prior to anesthesia induciton, EEG signatures will be recorded at Observer's Assessment of Alertness/Sedation (OAA/S) score of 5 (awake, eye-close state) for few minutes.
OTHER	OAA/S=3	Given sedative anesthetics (propofol, midazolam or dexmetomidine), EEG signatures will be recorded after reaching steady state of OAA/S=3 (responds only after name called loudly and/or repeatedly) for few minutes.
OTHER	OAA/S=1	Increasing drug concentration, EEG signatures will be recorded after reaching steady state of OAA/S=1 (does not respond to noxious stimuli) for few minutes.

Timeline

• Start date: 2020-06-18
• Primary completion: 2021-11-05
• Completion: 2021-11-05
• First posted: 2020-04-28
• Last updated: 2023-02-06

Locations

2 sites across 1 country: China